Table 1.
Overview of the datasets identified for analysis
| Dataset ID | Platform | Species | Sample | Number of samples | Reference |
|---|---|---|---|---|---|
| E-MTAB-463 and E-MTAB-465 | Agilent-014850 Whole Human Genome Microarray 4x44K G4112F | Homo sapiens | β-cells and α-cells | β-cells: 4 α-cells: 4 |
Dorrell et al., 2014 |
| – | RNA-seq | Homo sapiens | Sorted β-cells, α-cells and exocrine cells (duct and acinar) | β-cells: 3 α-cells: 3 Exocrine cells: 2 |
Bramswig et al., 2013 |
| EGAS00001000442 | RNA-seq | Homo sapiens | Sorted β-cells, α-cells and non-β-cells | 7 DNA libraries, pooled | Nica et al., 2013 |
| GSE30803 | [HG-U133A] Affymetrix Human Genome U133A Array | Homo sapiens | Islets (and 16 other primary cell types) | Islets: 3 | Martens et al., 2011 |
| – | RNA-seq | Mus musculus | β-cells and islets | Unknown. Data for 5 additional cell types downloaded from NCBI | Ku et al., 2012 |
| GSE13381 | [Rat230_2] Affymetrix Rat Genome 230 2.0 Array | Rattus norvegicus | β-cells and α-cells | β-cells: 2 Non-β-cells: 2 |
Kutlu et al., 2009 |
| GSE10785 | Rosetta/Merck Mouse 44 k 1.0 microarray | Mus musculus | Islets (and 5 other primary cell types) | Islets: 40 | Keller et al., 2008 |
| GSE35296 | RNA-seq | Homo sapiens | Islets | Control: 5 IL-1β and IFN-γ: 5 |
Eizirik et al., 2012 |
| – | [HG-U133A] Affymetrix Human Genome U133A Array | Homo sapiens | Islets | Control: 3 IL-1β and IFN-γ: 3 |
Ylipaasto et al., 2005 |
| – | [Rat230_2] Affymetrix Rat Genome 230 2.0 Array | Rattus norvegicus | FACS purified β-cells | For control and cytokine stimulation at each time point: 3 | Ortis et al., 2010 |
| – | [Rat230_2] Affymetrix Rat Genome 230 2.0 Array | Rattus norvegicus | INS-1E rat insulinoma cell line | For control and cytokine stimulation at each time point: 3 | Moore et al., 2011 |
| GSE40642 | [Rat230_2] Affymetrix Rat Genome 230 2.0 Array | Rattus norvegicus | INS-1ab rat insulinoma cell line | Control: 8 IL-1β: 20 PDX-1 overexpression: 8 PDX-1 overexpression and IL-1β: 20 |
Hansen et al., 2012 |
| GSE49786 | [Rat230_2] Affymetrix Rat Genome 230 2.0 Array | Rattus norvegicus | Islets | Untreated: 5 Pdx-1 overexpression: 5 |
Hayes et al., 2013 |
| E-MTAB-127 | A-CBIL-10-UPenn Mouse PancChip 6.1 | Mus musculus | Islets and MIN6 murine insulinoma cell line | Islets Pdx-1+/−: 3 Islets Pdx-1+/+: 3 MIN6 treated: 4 MIN6 control: 4 |
Sachdeva et al., 2009 |
| GSE12817 | [Rat230_2] Affymetrix Rat Genome 230 2.0 Array | Rattus norvegicus | Islets | 2 mM Glucose: 4 5 mM Glucose: 4 10 mM Glucose: 4 30 mM Glucose: 4 |
Bensellam et al., 2009 |
| GSE25724 | [HG-U133A] Affymetrix Human Genome U133A Array | Homo sapiens | Islets | Non-diabetic: 7 Diabetic: 6 |
Dominguez et al., 2011 |
| GSE20966 | [U133_X3P] Affymetrix Human X3P Array | Homo sapiens | β-cell-enriched pancreatic tissue | Non-diabetic: 10 Diabetic: 10 |
Marselli et al., 2010 |
| GSE38642 | [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] | Homo sapiens | Islets | Non-diabetic: 54 Diabetic: 9 |
Taneera et al., 2012 |