Table 1. Analysis of T125C SNP in African American cohort of Dallas Heart Study.
The DHS population was genotyped for the Caspase-12 T125C SNP using the Illumina HumanExome chip, as described in the Methods. The analysis was performed using linear regression, adjusted for age and BMI and stratified by gender.
Demographic, anthropometric and clinical characteristics of African American participants of the Dallas Heart Study stratified by gender and CASP12 R125X (rs497116) genotype.
| Characteristic | Female (N=1,412) | P- value |
Male (N=955) | P- value |
Total (N=2,367) | P- value |
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|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
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| TT (N=1042) |
TC (N=345) |
CC (N=25) |
TT (N=696) |
TC (N=238) |
CC (N=21) |
TT (N=1738) |
TC (N=583) |
CC (N=46) |
||||
| Age, years (N=2,367) | 46±11 | 44±11 | 45±8 | 0.14 | 45±11 | 44±11 | 47±12 | 0.87 | 45±11 | 44±11 | 46±10 | 0.22 |
| BMI, kg/m2 (N=2,349) | 32.2±8.3 | 32.6±7.7 | 35.3±6.9 | 0.038 | 28.6±6.4 | 29.4±7.1 | 29.6±7.3 | 0.13 | 30.7±7.8 | 31.3±7.6 | 32.6±7.6 | 0.011 |
| Glucose, mg/dLa (N=2,003) | 90±12 | 91±12 | 93±11 | 0.29 | 92±12 | 93±15 | 92±11 | 0.23 | 91±12 | 92±14 | 93±11 | 0.11 |
| HOMA-IR, Ub (N=2,031) | 4.5±4.4 | 4.8±4.1 | 5.2±3.3 | 0.37 | 4.3±5.0 | 4.6±5.8 | 5.7±7.7 | 0.37 | 4.5±4.6 | 4.7±4.9 | 5.4±5.7 | 0.92 |
| TG, mg/dLb (N=2,365) | 83 (61–114) | 78 (61–116) | 73 (63–87) | 0.76 | 91 (65–133) | 92 (66–134) | 85 (60–148) | 0.68 | 86 (63–122) | 84 (63–122) | 75 (60–120) | 0.60 |
| HTGC, % b (N=1,065) | 3.3 (1.9–5.1) | 3.3 (2.0–6.3) | 3.1 (1.6–3.8) | 0.47 | 3.1 (2.0–5.3) | 3.4 (2.0–5.3) | 2.4 (1.4–3.7) | 0.44 | 3.2 (2.0–5.2) | 3.3 (2.0–5.8) | 2.9 (1.1–3.9) | 0.96 |
| CRP (N=1,761) | 4.5 (1.8–9.6) | 5 (2.1–10.4) | 8.9 (5.7–12.8) | 0.056 | 2.2 (1.0–5.5) | 2.4 (1.1–6.7) | 2.0 (1.1–4.0) | 0.46 | 3.5 (1.4–8.1) | 3.9 (1.5–9.2) | 5.5 (2.0–10.0) | 0.058 |
Values are mean ±SD or median (interquartile range). Comparisons were made using linear regression models, adjusted for gender, age, and body-mass index, as necessary. The numbers in parentheses indicate the number of individuals with available data for each phenotype. BMI – body-mass index; TG – triglycerides; HTGC – hepatic triglyceride content.
Diabetic individuals excluded.
Analysis adjusted for diabetes in addition to other covariates.