Fig. 5.

ICG-001 reduces gastric cancer stem-like cells chemoresistance. a Effect of ICG-001 on the growth of established spheroids. Tumor spheres were allowed to form for 7 days, and then the established tumor spheres were incubated with ICG-001 and 5-Fu or cisplatin for another 7 days. The number and size of tumor sphere formed from GC cell lines with and without ICG-001 treatment were compared. b Drug resistant genes expression in MGC-803 under the treatment of ICG-001(25 μM). Data represent the mean ± SEM of three independent experiments. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. control