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. 2017 Sep 11;15:81. doi: 10.1186/s12915-017-0420-4

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© Godfray et al. 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1. — Driving endonuclease genes (DEGs) code for an endonuclease that targets a recognition site where it causes a double-strand break. The DEG is inserted in the chromosome in the same position where the recognition site occurs in the wild type. In a heterozygote, the DNA break is repaired using the homologue, leading to a DEG homozygote (after [13])