Fig. 2.

T_b in UBIKOR mice and controls. (A) Female and (B) male circadian temperature profiles showing that hypothermic response to 50% CR was more pronounced in mice with ubiquitous ablation of IGF-1R (UBIKOR) compared with control mice. (Lower) AL profiles. UBIKOR mice carry a Ubc-CreER^T2 transgene and homozygous IGF-1R^flox knock-in, controls are Ubc-CreER^T2 with wild-type IGF-1R alleles. Arrowheads indicate the 7 AM 50% CR meal. *P < 0.05; **P < 0.01; ***P < 0.001. n = 5 UBIKOR males, 6 control males, 7 UBIKOR females, 6 control females. Note that when we tested at intermediate points during the early daylight period (SI Appendix, Fig. S4; 10 AM), we found significantly low T_b also in AL-fed UBIKOR mice, similar to the findings in Igf1r^+/− females.