. 2017 Aug 21;114(36):9737–9742. doi: 10.1073/pnas.1618994114

Table S1.

Hazard ratios for mortality rate trials

Paradigm	Experiment ID (figure no.)	Populations compared	Hazard ratio^*	P value
Constant C:P	Fig. S4A	C + H₂O	0.79	0.11
	Fig. S4A	D + H₂O	0.79	0.11
		C	0.35	<0.000001
		D	0.35	<0.000001
	Fig. 5C	C	0.33	<0.000001
	Fig. 5C	C → D	0.33	<0.000001
		D	1.03	0.75
		C → D	1.03	0.75
		C	0.32	<0.000001
		C + H₂O	0.32	<0.000001
	Fig. 5C	C	0.36	<0.000001
	Fig. 5C	C → C + H₂O	0.36	<0.000001
		C + H₂O	1.02	0.84
		C → C + H₂O	1.02	0.84
Δ C:P		HP	0.29	<0.000001
		LP	0.29	<0.000001
		HP	0.43	<0.000001
		HP → LP	0.43	<0.000001
	Fig. 5D and Fig. S4C	LP	2.77	<0.000001
	Fig. 5D and Fig. S4C	HP → LP	2.77	<0.000001
		HP	0.52	<0.000001
		LP → HP	0.52	<0.000001
		LP	2.25	<0.000001
		LP → HP	2.25	<0.000001
		HP	0.37	<0.000001
		LP	0.37	<0.000001
		HP	0.57	<0.000001
		HP → LP	0.57	<0.000001
	Fig. S4 B and C	LP	1.33	0.00026
	Fig. S4 B and C	HP → LP	1.33	0.00026
		HP	0.61	<0.000001
		LP → HP	0.61	<0.000001
		LP	1.89	<0.000001
		LP → HP	1.89	<0.000001
Δ T	Fig. 5B	25 °C	0.26	<0.000001
		25 → 18 °C	0.26	<0.000001
		18 °C	42.8	<0.000001
		25 → 18 °C	42.8	<0.000001

Cox proportional hazards regression analysis. For data from Fig. S4A, lifelong mortalities were compared. For all other experiments, only mortality data following the treatment switch date were compared. When the hazard ratio is close to 1, the manipulation has little effect on survival. Lower or higher ratios indicate greater or poorer survival, respectively, of the second population in each comparison. P < 0.001 are in bold.