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The type of HG-KG interconversion may exist universally across from bacteria to eukaryotes. The distribution of the homologs of D2HGDH and SerA in bacteria were analyzed (A). Phylogenetic bootstrap consensus trees of D2HGDH (B) and SerA (C) in various organisms were constructed. According to the previous reports, the organisms in which SerA can reduce 2-KG to 2-HG were marked with red color. The sequence details were shown in SI Appendix, Table S1.
