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. 2017 Aug 21;114(36):E7545–E7553. doi: 10.1073/pnas.1620898114

Fig. 6.

Fig. 6.

Administration of C21 in C57BL/6 mice attenuates CNV. (A and B) Lesion size at 7 d after CNV induction was assessed by staining of choroidal flat-mount preparations with fluorescent isolectin B4 (A), and a cross-sectional area of lesions was quantified by SD-OCT (B), for C57BL/6 mice administered control vehicle or C21 (50 μg/kg/d) once a day immediately after laser photocoagulation. Data are presented as means ± SEM. ***P < 0.001. n = 37–48 lesions per experimental group. (C) Fluorescein leakage in CNV lesions was graded at 7 d after CNV induction in C57BL/6 mice administered control vehicle or C21 (50 μg/kg/d) once a day immediately after laser photocoagulation. The grade of the hyperfluorescent lesions is as follows: score 0 (i.e., no leakage); score 1 (i.e., debatable leakage); score 2A (i.e., definite leakage); score 2B (i.e., clinically significant leakage). n = 37–48 lesions per experimental group.