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. 2017 Aug 21;114(36):E7545–E7553. doi: 10.1073/pnas.1620898114

Fig. S2.

Fig. S2.

CYP-dependent ω-6 epoxides do not affect CNV. (A–F) Lesion size at 7 d after CNV induction was assessed by staining of choroidal flat-mount preparations with fluorescent isolectin B4 (A–C), and cross-sectional area of lesions was quantified by SD-OCT (D–F), for C57BL/6 mice administered 8,9-EET (A and D), 11,12-EET (B and E), and 14,15-EET (C and F) once a day immediately after laser photocoagulation. Data are presented as means ± SEM. (G–I) Fluorescein leakage in CNV lesions was graded at 7 d after CNV induction in C57BL/6 mice administered 8,9-EET (G), 11,12-EET (H), and 14,15-EET (I). n = 55–63 lesions per experimental group. The grade of the hyperfluorescent lesions is as follows: score 0 (i.e., no leakage); score 1 (i.e., debatable leakage); score 2A (i.e., definite leakage); score 2B (i.e., clinically significant leakage).