Fig. 3.

Associations of selective inhibitor combination benefit with mutation, cytogenetic, and surface antigen expression features in AML. (A) Scatter plots of combination/feature pairing test significance vs. difference in median CR between subgroups. Summaries for mutation (Left), cytogenetic (Middle), and surface antigens (Right). All plotted points correspond to combination/feature pairings in which (i) median IC₅₀ and AUC CR of the negative samples were not significantly <1 and (ii) positive and negative subgroups contained at least 15% of total evaluable samples each. Points above the horizontal dashed gray line demonstrated median IC₅₀ CR and AUC CR values for positive subgroup that were significantly <1 (i.e., FDR-adjusted P < 0.05). Points to the right of the vertical dashed gray line represent those in which the median IC₅₀ CR value of the positive subgroup was at least twofold lower than that of the negative subgroup. (B) Scatter plots of log-transformed IC₅₀ CR values for select combinations by AML mutation (Left), cytogenetic (Middle), and surface antigen expression subgroups (Right). Black horizontal bars represent median CR value. (*Median CR significantly <1 in that subgroup.)