Fig. S2.

Clustering of AUC-based effect measures of combination and single-agent efficacy for all 122 evaluated leukemia patient samples. (A) Unsupervised hierarchical clustering of AUC CR values for 122 patients with leukemia across 48 tested combinations. AUC CR values (defined as the ratio of the combination AUC to that of the smallest AUC of either drug alone) were log-transformed and row- and column-clustered by using a Pearson correlation pairwise average linkage method. Darker red color indicates lower CR values, and diagnostic category annotation of each sample is shown. (B) Single-agent AUC heat map for all 122 evaluated leukemia patient samples. AUC values for all samples across each of the 21 individually tested small-molecule inhibitors were normalized to the maximum possible AUC value of 286.27 and log-transformed. Patient samples are represented in columns in the identical clustered order as identified from the corresponding combination data in A. Darker red color indicates increased sensitivity, and the diagnostic category annotation of each sample is shown.