Fig. S3.

Distribution of IC₅₀ and AUC CRs across all tested patient samples. For each combination tested, frequency of samples with CR values are shown for IC₅₀ (A) and AUC (B) effect measures. Two different sets of cut points were examined: CR > 1/CR = 1/CR < 1 (Upper) or CR > 2/CR = 0.5–2/CR < 0.5 (Lower). Combinations are sorted according to frequency of samples with CR values <1 or <0.5, respectively. (C) Representative dose–response curves for patients with AML or CLL exhibiting CR values <1 for select combinations shown in Fig. 1E. Probit-derived curves for each single agent and the combination are shown.