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. 2017 Aug 21;114(36):E7441–E7449. doi: 10.1073/pnas.1705013114

Fig. 2.

Fig. 2.

A mouse DLBCL model recapitulates the pathophysiology of human DLBCL. (A) Schematic depiction of the development of the mouse model that mimics human DLBCL. (B) Western blot analysis showing higher PARP1 expression levels in DLBCL cells from mouse spleens compared with B cells from B6 mouse spleens. (C) Representative flow cytometry graphs showing that most immune cells (CD45+) in DLBCL mice express RFP and thus are derived from the transplanted HPCs. (D) Immunohistochemistry showing that the lymph nodes of DLBCL mice (n = 5) are larger than those of B6 mice (n = 5), and that most cells express RFP. (E) Immunohistochemistry results for the adjacent slides showing higher PARP1 expression levels in the lymph nodes of DLBCL mice (n = 5) compared with B6 mice (n = 5). Error bars represent SEM. *P < 0.05, ****P < 0.0001, nonparametric Student’s t test.