Fig. S4.

[¹⁸F]PARPi reveals DLBCL metastases in multiple tissues. (A) Biodistribution showing PARP1-specific accumulation of [¹⁸F]PARPi in multiple tissues from DLBCL mice injected with [¹⁸F]PARPi (n = 12), B6 mice injected with [¹⁸F]PARPi (n = 4), and DLBCL mice injected with [¹⁸F]PARPi and blocked with olaparib (n = 7). (B) Biodistribution in B6 mice showing PARP1-specific accumulation in lymph nodes, spleen, and salivary glands. B6 mice were injected with [¹⁸F]PARPi (n = 4) or preblocked with olaparib (n = 3). (C) Representative autoradiographs showing accumulation of [¹⁸F]PARPi in the selected tissues in DLBCL and B6 mice injected with [¹⁸F]PARPi and with additional olaparib blocking. (D) Representative histological images of the five tissues from DLBCL (n = 5) and B6 mice (n = 5). Consecutive sections were stained with H&E, PARP1, or RFP. Error bars represent SD. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001, nonparametric Student’s t test.