Fig. 4.

Indole extends reproductive span of C. elegans. (A) GO analysis of 494 TnaA- and Ahr-dependent genes using GOAmigo software. (B) Average number of embryos and oocytes (unfertilized) produced per day by N2 adults grown on K12 or K12ΔtnaA over time (n = 12 adult worms per condition). (C) Average number of oocytes produced by day 10 N2 adults in K12ΔtnaA plus indole or K12ΔtnaA plus vehicle (n = 12 worms per condition). (D) Average number of larvae obtained from mating day 10 N2 hermaphrodites grown in K12 and K12ΔtnaA with young males. (E) Average number of oocytes produced by day 10 N2 and ahr-1(ia3) adults in K12 and K12ΔtnaA conditions (n = 12 worms per condition). B–E are representative of at least two independent experiments.