Fig. 2.

(A and B) Probability distributions, (C and D) averages, and (E and F) SDs of the FPTs in (A, C, and E) wide ($g_n=\mathrm{\hspace{0.17em}1.5}\mu$m) and (B, D, and F) narrow ($g_n=\mathrm{\hspace{0.17em}0.5}\mu$m) channels with the same maximum half-width, $g_w=\mathrm{\hspace{0.17em}4.5}\mu$m. In A and B, experimental data (symbols) are compared with the outcome of BD simulations (curves) for the spatially modulated diffusivity, $D_{hyd}(x)$. The relevant channel profiles, $\pm g(x)$, are shown in A, Inset and B, Inset; vertical dashed segments mark the starting (red: $x=\mathrm{\hspace{0.17em}0}$) and ending (blue: $x=\pm \mathrm{\Delta }x$) positions of the first passage events. In C–F, experimental, numerical, and theoretical results are shown as solid symbols, open symbols, and solid curves, respectively. Numerical and theoretical results with constant $D_0$ and varying $D_{hyd}$ diffusivity are color-coded orange and green, respectively.