Fig. 2.

A catalytic water has the same position in structures of LTA₄H complexed with different ligands. Superposition of D375N-LTA₄ (residues are in green; LTA₄, catalytic water and Zn²⁺ are in orange) onto (A) LTA₄H-OPB-Pro (PDB ID code: 4MS6) (residues are in gray; OPB-Pro, catalytic water and Zn²⁺ are in light cyan), onto (B) structure of LTA₄H-captopril (PDB ID code: 4DPR) (residues are in beige; captopril, catalytic water and Zn²⁺ are in magenta), and onto (C) E271A-LTA₄ (residues are in cyan; LTA₄, catalytic water and Zn²⁺ are in yellow).