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The alternative conformation of LTA4 with an unbound C1 carboxylate, observed in closed LTA4H, may make a hydrogen bond to the hydroxyl group of Y383 in the context of the open enzyme. Superposition of open D375N (residues and Zn2+ are in magenta) onto (A) orthorhombic D375N (residues are in green, Zn2+ is in yellow) in complex with LTA4 (orange) and (B) onto orthorhombic E271A-LTA4 (residues are in cyan, Zn2+ is in yellow). Distances are labeled in Å.
