Table S2.

Structures of LTA₄H mutants in open conformation

#	Mutants	PDB ID code	Space group	Protein–ligand complex formation	Ligand in the active site	Conformation of dynamic domains	State of hydrophobic tunnel
1	D375N	5NIA	Trigonal	—	—	Open	Closed
2	D375N	5NID	Trigonal	Cocryst	—	Open	Open
3	R563A	5NIE	Orthorhombic	—	—	Open	2 Open/1 Closed*

^*The structure of R563A contains three molecules in the asymmetric unit.