Table 1.
Trials comparing hypofractionated and conventional prostate radiotherapy
| Trials | Prostate cancer patients | Centres | Recruitment | Hypofractionation | Conventional fractionation | Androgen deprivation therapy |
|---|---|---|---|---|---|---|
| HYPRO | Intermediate to high risk | Netherlands | 820 | 64.6 Gy in 19 fractions | 78 Gy in 39 fractions | 67% of patients |
| RTOG 0415 | Low risk | USA | 1115 | 70 Gy in 28 fractions | 73.8 Gy in 41 fractions | No |
| PROFIT | Intermediate risk | International (Canada, Australia and France) | 1206 | 60 Gy in 20 fractions | 78 Gy in 39 fractions | No |
| CHHiP | Low to high risk | UK | 3216 | 60 Gy in 20 fractions | 74 Gy in 37 fractions | Most patients |
CHHiP, Conventional or Hypofractionated High-Dose Intensity-Modulated Radiotherapy for Prostate Cancer; HYPRO, HYpofractionated irradiation for PROstate cancer; PROFIT, Prostate Fractionated Irradiation Trial; RTOG, Radiation Therapy Oncology Group.