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. Author manuscript; available in PMC: 2017 Sep 12.
Published in final edited form as: Neurogastroenterol Motil. 2012 Jun;24(6):503–512. doi: 10.1111/j.1365-2982.2012.01921.x

Table 1.

Examples of the variations in urine collecting periods in studies using excretion of orally administered probes to evaluate intestinal permeability in patients with IBS

Reference IBS group Probe In vivo/in vitro Urine collection timing (h) Permeability
Spiller et al.47 Post infectious (PI-IBS) Lactulose, mannitol In vivo 0–6 Increased
Marshall et al.48 IBS Sucrose, lactulose, mannitol In vivo Overnight Increased
Dunlop et al.54 IBS-D (PI and non-PI), IBS-C 51Cr-EDTA In vivo 0–3, 3–5, 5–24 Increased
Shulman et al.81 Children with IBS, and functional abdominal pain Sucrose, lactulose, mannitol, sucralose In vivo 0–3 Increased (sucrose/lactulose; sucralose/lactulose only)
Zhou et al.70 IBS-D Lactulose, mannitol In vivo 0–24 Increased in 39% of patients
Zhou et al.17 IBS-D Lactulose, mannitol In vivo 0–5, 6–24 Increased in 42% of patients

IBS, irritable bowel syndrome.