Table 5.
Predicted and actual data for selected three cut-off points with overall sensitivity, specificity, PPV and NPV for predicting patients with PCa ≥3+4 and patients with PCa Gleason ≥4+3. The number of cases missed by the algorithm were 16, 2, and 3 for Gleason 3+4, 4+3, and ≥4+3, respectively, using low cut-off; 9, 1, and 3 for Gleason 3+4, 4+3, and ≥4+3, respectively, using standard cut-off; and 3, 0, and 1 for Gleason 3+4, 4+3, and ≥4+3, respectively, using high cut-off.
| Cut-off | Neg | 3+3 | 3+4 | 4+3 | >4+3 | Total Missed | Sensitivity | Specificity | NPV | PPV | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≥3+4 | ≥4+3 | ≥3+4 | ≥4+3 | ≥3+4 | ≥4+3 | ≥3+4 | ≥4+3 | ||||||||
| Actual | 239 | 103 | 92 | 29 | 26 | ||||||||||
| Predicted | Low | 93 | 54 | 76 | 27 | 23 | 21 (4.3%) | 86% | 96% | 57% | 59% | 90% | 98% | 46% | 46% |
| Standard | 106 | 63 | 83 | 28 | 23 | 13 (2.7%) | 91% | 97% | 51% | 44% | 93% | 98% | 44% | 52% | |
| High | 148 | 70 | 89 | 29 | 25 | 4 (0.8%) | 97% | 99% | 36% | 37% | 97% | 99% | 40% | 40% | |