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. 2017 Aug 2;8(13):2561–2574. doi: 10.7150/jca.19972

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LHX6 suppresses the Wnt/β-catenin pathway. (A) LHX6 decreased the transcriptional activity of the Wnt/β-catenin pathway, as determined by a TOP flash/FOP flash reporter luciferase activity assay in LTEP-a-2 and SPC-a-1 cell lines. TOP and FOP flash plasmids were co-transfected with control vector or LHX6 and PRL-TK plasmids in LTEP-a-2 and SPC-a-1 cells. (B, C) LHX6 inhibited the expression of Wnt/β-catenin pathway target genes at both the mRNA and protein levels. Error bars indicate s.d. (n=3). * P<0.05; ** P<0.01.