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Metformin sensitizes leukemia cells to VCR-induced apoptosis. K562 or A301 cells were treated with or without 5 mM metformin in the presence or absence of 0.4 μM VCR for 24 h prior to Western blot analyses (A-B), MTS assay or trypan blue exclusion assay for cell viability (C-F) and FACS analyses for subG1 cell population (G). The data are presented as the mean ± SEM from three independent experiments (***P < 0.001; **P < 0.01).
