Table 2.
Univariate and multivariate analysis of parameters associated with overall survival in ccRCC patients with wild-type BAP1
| Variables | HR | 95% CI | P value |
|---|---|---|---|
| Univariate Cox regression analysis | |||
| Age (≥ 60 vs. <60) | 2.849 | 1.772-4.581 | <0.001 |
| Gender (male vs. female) | 0.949 | 0.613-1.469 | 0.815 |
| Ethnicity (Caucasians vs. non-Caucasians) | 1.147 | 0.362-3.635 | 0.816 |
| AJCC stage (Ⅲ+Ⅳ vs. Ⅰ+Ⅱ) | 4.874 | 3.023-7.857 | <0.001 |
| Tumor size (T3+T4 vs. T1+T2) | 3.791 | 2.427-5.922 | <0.001 |
| Metastasis status (M1 vs. M0) | 4.720 | 3.074-7.247 | <0.001 |
| Fuhrman grade (G3+G4 vs. G1+G2) | 2.645 | 1.619-4.319 | <0.001 |
| Surgical type (RN vs. PN) | 5.131 | 1.882-13.99 | 0.001 |
| Risk Score (High Risk vs. Low Risk) | 2.354 | 1.514-3.660 | <0.001 |
| Multivariate Cox regression analysis a | |||
| Age (≥ 60 vs. <60) | 2.341 | 1.452-3.775 | <0.001 |
| AJCC stage (Ⅲ+Ⅳ vs. Ⅰ+Ⅱ) | 2.664 | 1.529-4.642 | 0.001 |
| Metastasis status (M1 vs. M0) | 2.069 | 1.251-3.420 | 0.005 |
| Risk Score (High Risk vs. Low Risk) | 1.602 | 1.012-2.536 | 0.044 |
ccRCC, clear cell renal cell carcinoma; BAP1, BRCA1 associated protein-1; HR, hazard ratio; 95% CI, 95% confidential interval; AJCC, AJCC, American Joint Committee on Cancer; RN, radical nephrectomy; PN, partial nephrectomy.
a The final results after stepwise analysis with Backward (LR) method