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. Author manuscript; available in PMC: 2018 Apr 5.
Published in final edited form as: Neuron. 2017 Apr 5;94(1):93–107.e6. doi: 10.1016/j.neuron.2017.03.023

Figure 2. Nucleoporins Aggregate and Colocalize with mHtt in the zQ175 Mouse Model of HD.

Figure 2

(A,B) Coronal brain sections from 12 month old WT and HET zQ175 mice showing aggregates of RanGAP1 (red) that colocalize with EM48+ mHtt aggregates (green) in the striatum and cortex of HET zQ175 mice. (C,D) Coronal brain sections from 12 month old WT and HET zQ175 mice showing aggregates of NUP88 (red) that colocalize with EM48+ mHtt aggregates (green) in the striatum and cortex of HET zQ175 mice. (E,F,G) Quantification of number of RanGAP1 aggregates in the striatum and cortex of HET zQ175 mice at 2, 6, 9 and 12 months. (H,I,J) Quantification of diameter of RanGAP1 aggregates in the striatum and cortex of HET zQ175 mice at 2, 6, 9 and 12 months. Data (E–J) are presented as mean ± SEM. ***P<0.001 and ****P<0.0001 as analyzed by one-way ANOVA followed by Tukey’s post-hoc analysis. N = 3/age group. Scale bars, 10µm (A–D). See also Table S1, Figure S3.