Skip to main content
. Author manuscript; available in PMC: 2017 Sep 12.
Published in final edited form as: Nature. 2017 Mar 22;544(7648):120–123. doi: 10.1038/nature21714

Figure 2. A continuous cavity in the ADIPOR2 structure.

Figure 2

The large internal cavity is shown as surface (cavity mode 1) and coloured according to the Eisenberg hydrophobicity classification. (a) The extra electron density (2Fo-Fc contoured at 1σ) is shown in dark blue. The intracellular cavity extruding towards the N-terminus domain/TM1/TM2 is contoured in blue. (b) Highlighted in yellow are the two openings accessible to solvent (TM opening/Intracellular opening, shown in insets as surface views). The zinc ion and oleic acid are represented and coloured as in Fig. 1.