Table 1. IC50, SI and Log P values for complexes (1–4) and cisplatin in each cell line, after 24 h of incubation.
| Complex | IC50 ±SEM (μM) | ||||
|---|---|---|---|---|---|
| MDA-MB-231 | MCF-10A | MCF-7 | aSI | Log P | |
| Precursor | >200 | 81.87 ±7.87 | >200 | 0.41 | -0.40 ± 0.01 |
| (1) | >200 | 42.75 ± 5.02 | >200 | 0.21 | 0.26 ± 0.06 |
| (2) | 52.74 ± 0.62 | 31.46 ± 1.06 | >200 | 0.60 | 0.55 ± 0.02 |
| (3) | >200 | 42.18 ± 2.37 | >200 | 0.21 | 0.06 ± 0.008 |
| (4) | 31.16 ± 0.04 | 48.89 ± 0.09 | >200 | 1.57 | 0.77 ± 0.03 |
| Cisplatin | 2.43±0.20 | 29.45 ± 0.85 | 79.18 ± 0.20 | 12.20 | -2.53b |
Precursor: cis-[RuCl2(dppb)(bipy)]. SEM = Standard error of the mean.
a(SI) Selectivity index of the compounds are calculated as described in Methods section.
bLog P of cisplatin was based on Buss et al. [22].