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. 2017 Sep 12;14(9):e1002383. doi: 10.1371/journal.pmed.1002383

Table 1. Table of HbA1c associated variants.

Table with results and classification of the 60 HbA1c-associated variants. SNP number corresponds to number in Fig 1.

SNP Markername Chr. Position (bp) Effect Allele Other Allele Gene Status Signals Classification European ancestry
METAL
p-value		 Trans-ethnic MANTRA log10BF
1 rs2375278 1 25401625 A G SYF2 Novel Single Unclassified 2.03 × 10−7 6.93
2 rs267738 1 149207249 T G CERS2 Novel Single Unclassified 2.59 × 10−9 6.41
3 rs12132919 1 154584765 A C TMEM79 Known Single Erythrocytic 0.0169 10.08
4 rs857691 1 156893002 T C SPTA1 Known Single Erythrocytic 3.97 × 10−25 25.52
5 rs17509001 2 23874735 C T ATAD2B Novel Single Unclassified 1.94 × 10−15 13.30
6 rs12621844 2 48268239 T C FOXN2 Novel Single Unclassified 1.87 × 10−8 5.32
7 rs13387347 2 169463092 T C G6PC2 Novel Multiple Glycemic 0.308 5.77
8 rs560887 2 169471394 C T G6PC2 Known Multiple Glycemic 1.48 × 10−58 55.77
9 rs17256082 2 175000610 C T SCRN3 Novel Single Unclassified 0.00112 6.27
10 rs7616006 3 12242648 A G SYN2 Novel Single Erythrocytic 5.07 × 10−10 10.16
11 rs9818758 3 49357929 A G USP4 Novel Single Unclassified 7.74 × 10−10 7.20
12 rs11708067 3 124548468 A G ADCY5 Novel Single Glycemic 1.42 × 10−12 10.62
13 rs8192675 3 172207577 T C SLC2A2 Novel Single Glycemic 1.38 × 10−11 10.33
14 rs4894799 3 173278234 A G FNDC3B Novel Single Unclassified 1.80 × 10−6 6.05
15 rs13134327 4 144879245 A G FREM3 Novel Single Glycemic 2.64 × 10−15 12.66
16 rs11954649 5 156988069 G C SOX30 Novel Single Unclassified NA 6.20
17 rs7756992 6 20787688 G A CDKAL1 Known Single Glycemic 2.80 × 10−12 16.53
18 rs1800562 6 26201120 G A HFE Known Multiple Erythrocytic 4.67 × 10−28 26.81
19 rs198846 6 26215442 G A HFE Novel Multiple Erythrocytic 1.18 × 10−23 23.72
20 rs11964178 6 109668728 A G C6orf183 Novel Single Erythrocytic 6.38 × 10−10 7.03
21 rs11154792 6 135473333 T C MYB Known Single Erythrocytic 7.45 × 10−18 17.89
22 rs592423 6 139882386 A C CITED2 Novel Single Erythrocytic 3.96 × 10−8 4.50
23 rs2191349 7 15030834 T G DGKB Novel Single Glycemic 2.09 × 10−7 6.63
24 rs4607517 7 44202193 A G GCK Known Multiple Glycemic 8.76 × 10−38 51.28
25 rs3824065 7 44213783 C T GCK Novel Multiple Glycemic 4.22 × 10−35 31.87
26 rs6474359 8 41668351 T C ANK1 Known Multiple Unclassified 1.50 × 10−16 14.88
27 rs4737009 8 41749562 A G ANK1 Known Multiple Erythrocytic 4.48 × 10−27 32.08
28 rs6980507 8 42502241 A G SLC20A2 Novel Single Erythrocytic 3.58 × 10−8 8.73
29 rs11558471 8 118254914 A G SLC30A8 Known Single Glycemic 1.38 × 10−19 23.26
30 rs2383208 9 22122076 A G MTAP Novel Single Glycemic 7.04 × 10−12 11.74
31 rs7040409 9 90693056 C G C9orf47 Novel Single Erythrocytic 2.56 × 10−14 11.29
32 rs1467311 9 109576753 G A KLF4 Novel Single Unclassified 2.09 × 10−7 8.72
33 rs579459 9 135143989 C T ABO Novel Single Glycemic 9.42 × 10−9 10.14
34 rs4745982 10 70759849 T G HK1 Known Multiple Erythrocytic 2.87 × 10−65 63.05
35 rs10823343 10 70761019 A G HK1 Novel Multiple Unclassified 1.68 × 10−55 49.45
36 rs17747324 10 114742493 C T TCF7L2 Known Single Glycemic 6.12 × 10−11 8.49
37 rs3782123 11 195198 C A BET1L Novel Single Unclassified 1.51 × 10−10 9.51
38 rs2237896 11 2815016 G A KCNQ1 Novel Single Glycemic 0.00246 6.07
39 rs174577 11 61361390 C A FADS2 Novel Single Glycemic 5.45 × 10−7 8.45
40 rs11603334 11 72110633 G A ARAP1 Novel Single Glycemic 6.85 × 10−9 6.53
41 rs10830963 11 92348358 G C MTNR1B Known Single Glycemic 2.23 × 10−23 26.64
42 rs11224302 11 99961814 C T CNTN5 Novel Single Erythrocytic 4.76 × 10−7 6.40
43 rs2110073 12 6946143 T C PHB2 Novel Single Unclassified 4.44 × 10−8 7.18
44 rs2408955 12 46785398 T G SENP1 Novel Single Erythrocytic 1.42 × 10−15 11.65
45 rs10774625 12 110394602 G A ATXN2 Novel Single Erythrocytic 1.46 × 10−8 6.38
46 rs11619319 13 27385599 G A PDX1 Novel Single Glycemic 4.58 × 10−7 8.38
47 rs576674 13 32452302 G A KL Novel Single Glycemic 1.39 × 10−5 6.38
48 rs282587 13 112399663 G A ATP11A Known Single Unclassified 1.70 × 10−12 13.92
49 rs9604573 13 113571085 T C GAS6 Novel Single Unclassified 9.60 × 10−9 6.72
50 rs11248914 16 233563 T C ITFG3 Novel Single Erythrocytic 2.56 × 10−14 10.60
51 rs1558902 16 52361075 A T FTO Novel Single Unclassified 3.27 × 10−8 6.88
52 rs4783565 16 67307691 A G CDH3 Novel Single Erythrocytic 1.73 × 10−7 6.73
53 rs837763 16 87381230 T C CDT1 Known Single Erythrocytic 1.68 × 10−28 28.89
54 rs9914988 17 24207230 A G ERAL1 Novel Single Erythrocytic 2.77 × 10−11 11.34
55 rs2073285 17 73628956 C T TMC6 Novel Single Unclassified 1.27 × 10−4 6.47
56 rs1046896 17 78278822 T C FN3KRP Known Single Unclassified 4.46 × 10−64 71.79
57 rs11086054 19 17107737 A T MYO9B Novel Multiple Unclassified 8.16 × 10−6 9.12
58 rs17533903 19 17117523 A G MYO9B Known Multiple Erythrocytic 5.27 × 10−12 9.912
59 rs4820268 22 35799537 G A TMPRSS6 Known Single Erythrocytic 1.40 × 10−22 20.79
60 rs1050828 X 153417411 T C G6PD Novel Single Erythrocytic NA* NA

*African American meta-analysis p-value for the G6PD variant (rs1050828) = 8.23 × 10−135. Chr, chromosome; MANTRA, Meta-Analysis of Transethnic Association