Table 1.
Substrate | IC50 value ± SDa (μmol/L) |
Resistance foldb | |
---|---|---|---|
KB-3-1 | KB/ATO | ||
ATO | 2.07 ± 0.92 | 21.07 ± 2.47 | 10.04* |
APT | 16.29 ± 7.19 | 220.36 ± 40.41 | 13.52* |
6-MP | 7.86 ± 0.84 | 68.84 ± 2.88 | 8.75* |
Cisplatin | 1.66 ± 1.46 | 8.43 ± 2.43 | 5.07* |
Vincristine | 0.067 ± 0.036 | 0.20 ± 0.039 | 2.98* |
Paclitaxel | 0.054 ± 0.019 | 0.080 ± 0.013 | 1.48 |
Doxorubicin | 0.91 ± 1.14 | 1.56 ± 1.23 | 1.71 |
Mitoxantrone | 0.25 ± 0.22 | 0.23 ± 0.18 | 0.92 |
IC50 values are represented as mean±SD of three independent experiments performed in triplicate.
Resistance fold was calculated by dividing the IC50 values of substrates by the IC50 of parental cells.
P < 0.05 versus parental cells.