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. 2017 Sep 12;12(9):e0183539. doi: 10.1371/journal.pone.0183539

Table 2. Acromegaly symptoms in the whole cohort.

Acral enlargement symptoms N = 1477
n (%)
Increased ring size 260 (17.6)
Increased shoe size 159 (10.8)
Lips or jaw enlargement 87 (5.9)
Tooth space widening 112 (7.6)
Tongue enlargement 55 (3.7)
Paresthesia in hands 380 (25.7)
Other typical acromegaly symptoms
Headaches 355 (24.0)
Hoarse voice 261 (17.7)
Arthralgia 706 (47.6)
Menstrual disturbances (n = 273) 61 (4.1)
Erectile dysfunction (n = 930) 237 (16.0)
Diabetes 226 (15.3)
High blood pressure 630 (42.7)
Fatigue 810 (54.8)
Excessive perspiration 442 (29.9)