Fig 7. Modeled gating currents and ionic currents are similar to experimental recordings.
(A1-4) Sample experimental and simulated gating currents and ionic currents for C373F NaV1.5 at pH 7.4. (B) Overlaps of outward gating current traces recorded from 6 different cells expressing C373F NaV1.5 at pH 7.4 with simulated outward gating currents at the same membrane potentials. Gating currents were normalized to the peak outward current at 40mV. (C) Overlaps of ionic current traces recorded from 6 different cells expressing C373F NaV1.5 at pH 7.4 with simulated ionic currents at the same membrane potentials. Ionic currents were normalized to the peak inward current at 20mV. Overall the model replicates the experimental ionic and gating currents at different membrane potentials.