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. 2017 Sep 12;12(9):e0184605. doi: 10.1371/journal.pone.0184605

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© 2017 Peters et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 9 — (A1-A4) Sample ionic currents recorded from IFM/QQQ and IFM/QQQ-E1784K Na_V1.5 at pH 7.4 and pH 6.0. (B) Simulated outward charge-voltage and conductance-voltage relationships from C373F and C373F/E1784K Na_V1.5 models at pH 7.4. To replicate the hyperpolarizing shift in the midpoint of the charge-voltage relationship and the depolarizing shift in the midpoint of the conductance voltage-relationship in the E1784K model required only changes to DIVS4 movement to correspond to experimental data on fast inactivation (C) Conductance-voltage relationships of IFM/QQQ and IFM/QQQ-E1784K Na_V1.5 at pH 7.4 and pH 6.0. In the absence of fast inactivation, the E1784K mutant does not significantly affect the conductance-voltage relationship.