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From cariprazine to the G protein-biased D2 agonists62
| |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Compound | cAMP
|
pERK1/2
|
cAMP–pERK1/2
|
||||||
| pKA | Logτ | Log(τ/KA) | Δlog(τ/KA) | pKA | Logτ | Log(τ/KA) | Δlog(τ/KA) | ΔΔlog(τ/KA) | |
| 8 | 8.71 | 0.85 | 9.59 | 1.04 | 7.61 | −0.37 | 7.25 | −1.3 | 2.34 |
| 9 | 7.11 | 0.76 | 7.92 | −0.63 | 7.51 | −0.31 | 7.21 | −1.34 | 0.71 |
