Table 2.
pD2 and Emax values for agonists-induced contraction in aorta and second-order mesenteric arteries from rats treated with a high-fat diet or control diet for 12 weeks.
| Control diet 12 weeks (n=6) |
HFD 12 weeks (n=6) |
|||
|---|---|---|---|---|
|
| ||||
| pD2 | Emax | pD2 | Emax | |
| Aorta | ||||
| PE | 7.37 ± 0.07 | 103.1 ± 2.7 | 7.35 ± 0.10 | 106.8 ± 8.5 |
| 5-HT | 5.91 ± 0.13 | 115.1 ± 3.0 | 5.87 ± 0.05 | 118.9 ± 11.5 |
| ET-1 | 8.31 ± 0.08 | 125.8 ± 3.0 | 8.32 ± 0.09 | 132.9 ± 11.6 |
| Mesenteric artery | ||||
| PE | 5.79 ± 0.08 | 121.4 ± 2.8 | 5.92 ± 0.14 | 117.8 ± 2.9 |
| 5-HT | 6.45 ± 0.14 | 116.7 ± 2.5 | 6.49 ± 0.11 | 118.3 ± 2.0 |
| ET-1 | 7.87 ± 0.18 | 116.9 ± 4.6 | 7.93 ± 0.11 | 120.2 ± 1.6 |
The results are presented as mean ± SEM of n = 6 in each experimental group. The pD2 values are −logEC50 and Emax values are represented as the percentage of contraction induced by 120 mM KCl. HFD, high fat diet.