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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Genes Brain Behav. 2017 May 2;16(7):699–708. doi: 10.1111/gbb.12384

Figure 2. Midkine knockout mice do not differ in saccharin or quinine intake compared with controls.

Figure 2

Male (a, c) and female (b, d) wild type (Mdk +/+, black bars) and homozygous midkine knockout (Mdk −/−, white bars) mice underwent a 2-bottle choice test for water and saccharin (0.03 or 0.06%, w/v) or water and quinine (15 or 30 μM). (a, b) Saccharin consumption plotted as the ratio of the volume of saccharin solution consumed over total fluid consumed. There were no significant effects of genotype, but there were significant main effects of saccharin concentration for both sexes. Male Mdk +/+, n = 9; male Mdk −/−, n = 7; female Mdk +/+, n = 6; female Mdk −/−, n = 9. ** P < 0.01, *** P < 0.001 by two-way ANOVA. (c, d) Quinine consumption plotted as the ratio of the volume of quinine solution consumed over total fluid consumed. There were no significant differences between genotypes or quinine concentration. Male Mdk +/+, n = 6; male Mdk −/−, n = 5; female Mdk +/+, n = 4; female Mdk −/−, n = 6. Data are presented as the mean ± SEM.