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. Author manuscript; available in PMC: 2018 Sep 11.
Published in final edited form as: Curr Biol. 2017 Aug 24;27(17):2600–2609.e4. doi: 10.1016/j.cub.2017.07.063

Figure 3. GABAAR activity of ON-cBC dendrites depends on endogenous activation of ON-cBC dendritic D1Rs.

Figure 3

In rabbit retinal slices superfused with medium that contained dopamine (5 μM) and TPMPA (50 μM) and in which synaptic transmission was blocked with cobalt (2 mM), GABA (0.5 mM) was puffed onto BC dendrites (time of puff is indicated by shaded vertical lines) by pressure ejection. GABA responses were clearly evident under dopamine (control) conditions (A) with an average GABA reversal potential (EGABA) = −42.2 ± 2.6 (SEM) mV (n=5), but were much reduced in the presence of SCH (5 μM) (B) and when the superfusate did not contain dopamine (C). (D) When GABA was puffed at −70 mV, average peak GABAAR response size was significantly greater (p < 0.01) when the superfusate contained dopamine (DOPA CTL; 17.6 ± 1 mV; n=5) compared to when it contained dopamine and SCH (DOPA + SCH; 5.6 ± 2.4 mV; n=5) or did not contain dopamine (NO DOPA; 4.8 ± 1.6 mV; n=5).