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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Biochim Biophys Acta. 2017 Jul 25;1862(10 Pt B):1221–1232. doi: 10.1016/j.bbalip.2017.07.009

Figure 4. Schematic model of perilipin 2 function in cells under basal and lipolytically stimulated conditions.

Figure 4

Perilipin 2 localizes almost exclusively to lipid droplets and does not significantly recruit ATGL, ABHD5, or HSL to lipid droplets under either basal or lipolytically stimulated conditions. Perilipin 2 is relatively permissive to lipolysis; lipolysis under basal conditions is approximately comparable to lipolysis when PKA is activated. Perilipin 2 is not a substrate for PKA, although HSL, ATGL, and ABHD5 are substrates. The localization of ATGL with ABHD5 and HSL to perilipin 2 coated lipid droplets is likely transient under both conditions. It is unknown whether or not perilipin 2 affects MAGL localization or activity.