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. 2017 Aug 11;16(5):1168–1179. doi: 10.1111/acel.12653

Figure 2.

Figure 2

Overexpression of valosin‐containing protein (VCP) attenuated pressure overload‐induced cardiac hypertrophy. (A) The construct of the VCP cardiac‐specific transgenic mouse. The mRNA level (B) and protein levels (C) of VCP in the left ventricles (LVs) of wild‐type (WT) mice and VCP TG mice. *P < 0.01 vs. WT mice. N = 4/group. (D) Representative images of echography of mouse hearts. Quantitated data of LV anterior or posterior wall thickness of end‐diastolic phase (LVAWd) (E) and (LVPWd) (F), LV internal diameter at the end‐diastolic stage (LVIDd) (G), ejection fraction (EF) (H), fractional shortening (FS) (I). (J) Representative curves of aortic pressure recorded via an invasive pressure catheter. Quantitated data of aortic systolic blood pressure (ASBP) (K), LV end end‐diastolic pressure (LVEDP) (L), maximal dp/dt (M), and minimal dp/dt (N). *P < 0.01 vs. sham. # P < 0.01 vs. WT TAC mice. N = 5/group for (E) to (N). Data are shown as mean ± SEM, one‐way ANOVA was used in (B) and (C), and two‐way ANOVA was used in Fig.E to I and K to N.