Figure 3.

Remodelling of small mesenteric arteries occurs with age in PMCA1^Ht mice and before a detectable increase in BP. (A) The internal lumen diameter does not significantly differ between passive mesenteric arteries from WT and PMCA1^Ht mice at 6 months of age but is significantly smaller in PMCA1^Ht mice at 9 and 18 months (B & C). (D) Wall thickness is similar at 6 months of age and significantly increases with age in PMCA1^Ht arteries (E & F). (G, H. and I) The vessel wall thickness to lumen ratio (W:L) is significantly increased in arteries from PMCA1^Ht mice aged 6, 9 and 18 months old. (J, K and L) The cross‐sectional area (CSA) of the vessel wall is not significantly different between arteries taken from WT and PMCA1^Ht mice at any age tested. Extra sum of squares F‐test analysis was performed. All data were plotted as mean value ± SEM. n = 4–8 *P < 0.05, **P < 0.01, ***P < 0.001.