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. 2017 Jun 14;16(5):1191–1194. doi: 10.1111/acel.12627

Figure 1.

Figure 1

SKN‐1 is required for daf‐16(oe) Oxr but not Age. (A–C) skn‐1 is required for daf‐16(oe) Oxr. One representative trial shown in each case. (A) 5 mm t‐BOOH. daf‐16(oe) increases survival by +14.1%, P < 0.0001 (log rank test; combined data from 3 trials). (B) 2.5 mm sodium arsenite. daf‐16(oe) increases survival by +34.1%, P < 0.0001 (log rank test; representative data from 2 trials). (C) 100 mm Paraquat. daf‐16(oe) increases survival by +34.2%, P < 0.0001 (log rank test; combined data from 3 trials). (D) daf‐16(oe) (zIs356) Age does not require SKN‐1 (trial 1 in Table S1). (E,F) daf‐16(oe) Age is not suppressed by skn‐1 RNAi (both trial 1 in Table S1). (G) Age resulting from intestine‐specific daf‐16(oe) is not suppressed by skn‐1 RNAi (trial 1 in Table S1). Assays performed at 20 °C with 40 μm (D) or 80 μm FUDR (E–G).