Figure 2.

Aged female mice with combined deficiency in Cnr1 and Cnr2 receptors exhibit high bone mass. Trabecular and cortical bone parameters in Cnr1/2 double‐knockout (Cnr1/2^−/−) CD1 mice (n = 9) and wild‐type (wt, n = 7) control assessed at 12 months of age at the tibia, femur and vertebrae L6 by microCT (a: trabecular volume, BV/TV (%); b, trabecular separation, Tb.Sp. (μm); d, cortical area, Ct.Ar. (μm²) e; cortical thickness, Ct. Th. (μm). (c and f) Representative microCT images of trabecular (c) and cortical bone (f) from tibiae and femur of the mice in panels a, b, d, e. Values are mean ± SEM. Significant differences between WT and Cnr1/2^−/− groups are indicated by *P < 0.05, **P < 0.01 and ***P < 0.001.