Figure 3.

Increased bone strength in aged female mice with combined deficiency in Cnr1 and Cnr2 receptors. Bone strength parameters in Cnr1/2 double‐knockout (Cnr1/2^−/−) CD1 mice and wild‐type (wt) control assessed at 3 and 12 months of age at the tibial and femoral diaphysis by three‐point bending (a, Failure, Newton; b, Fracture, Newton; c, Maximum stiffness, Newton; d, Yield, Newton). Values are mean ± SEM from at least six mice per group. Significant differences between WT and Cnr1/2^−/− groups are indicated by **P < 0.05. Pearson's correlation analyses were performed across 12‐month‐old wild‐type and Cnr1‐ and Cn2‐deficient mice groups between cortical area (Ct.Ar) and peak failure (e) and (f) facture loads at the femoral diaphysis. Pearson correlation coefficients (R) are indicated on each graph. *P < 0.05 indicates significant correlation between variables.