Table 1.
Static and dynamic histomorphometry in Cnr1/2 double‐knockout (Cnr1/2−/−) and wild‐type mice
| Age | Genotype | Oc.N/BS (cells mm−1) | Act.Res/BS (%) | Ob.N/BS (cells mm−1) | MAR (μm day−1) | MS/BS (%) | BFR/BS (μ)m3 (μ)m−2 day−1 | AdipoS/BS (%) |
|---|---|---|---|---|---|---|---|---|
| 3 months | Wild‐type | 0.78 ± 0.18 | 2.45 ± 0.19 | 22.5 ± 1.6 | 4.1 ± 0.2 | 51.9 ± 1.5 | 2.1 ± 0.2 | 0.013 ± 0.01 |
| CNR1/2−/− | 0.60 ± 0.16* | 1.9 ± 0.12* | 17.9 ± 1.0 | 4.3 ± 0.1 | 51.6 ± 0.8 | 2.2 ± 0.1 | 0.011 ± 0.01 | |
| 12 months | Wild‐type | 1.7 ± 0.2 | 4.9 ± 0.5 | 17.6 ± 1.5 | 1.7 ± 0.4 | 46.8 ± 1.7 | 0.8 ± 0.05 | 0.09 ± 0.01 |
| CNR1/2 −/− | 1.4 ± 0.1* | 4.5 ± 0.4** | 11.7 ± 0.1** | 1.8 ± 0.1 | 32.8 ± 2.6** | 0.6 ± 0.06** | 0.30 ± 0.07** |
Act.Res; active resorption surface/bone surface (%); Oc.N/BS, osteoclast number/bone surface (cells/mm); AdipoS/BS, adipocyte surface/bone surface (%); Ob.N/BS, osteoblast number /bone surface (cells/mm); MAR, mineral apposition rate (μm day−1); MS/BS, mineralizing surface/bone surface (%); BFR/BS: bone formation rate/bone surface (μ)m3 (μ)m−2 day−1; values are means ± SEM and are obtained from six to eight animals. *P < 0.05, **P < 0.01 between genotype groups.