Table 2.
Body weight and morphometric measurements of control rats (CTR) and rats with heart failure (MCT) after 14 days of p.o. administration with the PTS : HPβCD complex at 25, 50 or 100 mg·kg−1 dose
| Groups | Initial BW (g) | BW variation (%) | RV gross weight (mg) | RV weight/tíbia (mg·mm−1) | RV weight/LV weight (mg·mg−1) |
|---|---|---|---|---|---|
| CTR0 | 238 ± 9.2 | 53.3 ± 3.0 | 200 ± 13.3 | 5.9 ± 0.4 | 0.31 ± 0.02 |
| CTR25 | 243 ± 9.2 | 49.6 ± 3.0 | 197 ± 13.0 | 5.4 ± 0.3 | 0.28 ± 0.02 |
| CTR50 | 231 ± 10.6 | 55.9 ± 3.5 | 188 ± 15.2 | 5.0 ± 0.5 | 0.27 ± 0.02 |
| CTR100 | 250 ± 9.21 | 54.8 ± 3.0 | 192 ± 13.2 | 5.3 ± 0.4 | 0.29 ± 0.02 |
| MCT0 | 238 ± 9.5 | 35.6 ± 2.3a | 291 ± 9.9a | 8.0 ± 0.3a | 0.48 ± 0.01a |
| MCT25 | 248 ± 6.9 | 37.0 ± 2.1a | 259 ± 10.0a | 7.2 ± 0.4a | 0.42 ± 0.02a |
| MCT50 | 236 ± 6.5 | 33.0 ± 2.3a | 262 ± 9.9a | 7.3 ± 0.4a | 0.43 ± 0.01a |
| MCT100 | 254 ± 6.9 | 30.1 ± 3.0a | 222 ± 10.0a , b | 6.2 ± 0.30a , b | 0.34 ± 0.01b , c |
Values are expressed as mean ± SD, n = 8 animals per group. Two‐way ANOVA and Tukey's post hoc tests were performed. BW, body weight.
a
Significantly different compared with CTR (P < 0.05).
b
Significantly different compared with MCT0 (P < 0.05).
c
Significantly different compared with MCT25 and MCT50 (P < 0.05).