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. 2017 Aug 17;174(19):3284–3301. doi: 10.1111/bph.13947

Figure 9.

Figure 9

Hyaluronan affects PASMC properties. Cellular proliferation (A) and cytotoxicity (B) from cells exposed to HMW, MMW, LMW or ULMW hyaluronan treated with PBS or fasudil (100 μM). Migration assay for MMW, LMW and ULMW (C). Atomic force microscopy experiments showing increased cells stiffness using Young's modulus for PASMC treated with media only, MMW or ULMW HA (D). Detail of the positioning of the AFM tip on the centre of a PASMC (E). * P ≤ 0.05, significant difference between media and MWM + PBS, LMW + PBS or ULMW + PBS experimental, ANOVA. # P ≤ 0.05, significant difference between PBS and fasudil treatment groups; unpaired Student's t‐test.