Table 4.
Incidence rate ratios (IRR) for RSVH and geometric mean ratios for duration of RSVH in children with chronic conditions from the Danish RSV database [10]
| Conditiona | RSV/Total (%) | IRR (95% CI); P value | GMR for LOSb (95% CI); P value |
|---|---|---|---|
| Congenital | |||
| Malformations of respiratory system | |||
| Cleft lip and palate | 50/855 (6.4) | 1.5 (1.1–2.0); 0.004 | 1.0 (0.8–1.3); NS |
| Malformations of the larynx; trachea and bronchi | 41/440 (9.3) | 1.5 (1.1–2.1); 0.009 | 1.1 (0.8–1.5); NS |
| Malformation of the lungs | 7/51 (13.7) | 2.2 (1.0–4.8); 0.049 | 1.5 (0.7–3.2); NS |
| Other conditions associated with respiratory symptoms | |||
| Esophageal atresia | 26/115 (22.6) | 2.8 (1.6–4.9); <0.001 | 1.8 (1.1–3.1); 0.022 |
| Neuromuscular disease | |||
| Encephalocele | 58/542 (10.7) | 1.5 (1.1–2.1); 0.005 | 1.1 (0.8–1.4); NS |
| Spina bifida and malformations of the spinal cord | 17/172 (9.9) | 2.2 (1.3–3.6); 0.002 | 2.1 (1.3–3.3); 0.003 |
| Muscular dystrophy | 13/82 (15.9) | 2.5 (1.4–4.6); 0.003 | 1.5 (0.9–2.4); NS |
| Cerebral palsy | 93/905 (10.3) | 1.6 (1.3–2.0); <0.001 | 1.3 (1.1–1.6); 0.005 |
| Congenital diseases, chromosomal abnormalities, and others | |||
| Malformations of the urinary systemc | 82/1232 (6.7) | 1.5 (1.2–1.9); <0.001 | 1.0 (0.8–1.2); NS |
| Other chromosomal abnormalities | 4/17 (23.5) | 5.1 (1.7–15.5); 0.004 | 1.6 (0.7–3.8); NS |
| Malformations of the GI tract, liver, biliary system, pancreas, and abdominal wall | 94/1078 (8.7) | 1.6 (1.3–2.0); <0.001 | 1.2 (1.0–1.5); NS |
| Congenital immunodeficiencies | 26/122 (21.3) | 2.4 (1.6–3.5); <0.001 | 1.2 (0.9–1.8); NS |
| Inborn errors of metabolism | 29/276 (10.5) | 2.4 (1.6–3.5); <0.001 | 1.1 (0.8–1.5); NS |
| Acquired | |||
| Interstitial lung disease | 3/11 (27.3) | 6.5 (1.7–23.9); 0.005 | 1.3 (0.4–4.1); NS |
| Gastroesophageal reflux | 40/610 (6.6) | 1.5 (1.1–2.1); 0.019 | 1.0 (0.7–1.3); NS |
| Epilepsy | 75/713 (10.5) | 2.6 (2.1–3.4); <0.001 | 1.6 (1.3–2.0); <0.001 |
| Acquired heart disease | 53/427 (12.4) | 2.0 (1.5–2.7); <0.001 | 1.1 (0.8–1.4); NS |
| Liver disease | 9/48 (18.7) | 4.0 (2.0–8.2); <0.001 | 1.0 (0.6–1.9); NS |
CI confidence interval, GI gastrointestinal, GMR geometric mean ratio, LOS length of stay for RSVH, IRR incidence rate ratio, NS not significant, RSV respiratory syncytial virus, RSVH respiratory syncytial virus hospitalization
aExcludes the following conditions all of which were identified as significant risk factors for RSVH: CLD, CHD (both out with remit of review), Down syndrome, cancer and cystic fibrosis (data presented in relevant sections of this paper and Tables 1, 2 and 3, respectively)
bPresence vs. no presence of condition
cIncluding vesicoureteral reflux and obstructive renal disease