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. 2017 Sep 12;7:11420. doi: 10.1038/s41598-017-11645-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term effects of chronic THC exposure during adolescence on spontaneous mPFC putative pyramidal neuron activity. (A) Microphotograph of a representative mPFC neuronal recording placement. (B) Adolescent THC pretreated rats displayed increasing spontaneous PFC putative pyramidal neuronal firing frequency. (C) Greater proportion of bursting neurons was observed in adolescent THC exposed rats when compared to VEH controls (75.41% vs. 57.58%). (D) Representative rastergrams showing spontaneous activity of putative PFC pyramidal neurons in THC (top) vs. VEH pretreated rats (bottom). (E) Firing frequencies of bursting cells, not tonic cells, were significantly higher in adolescent THC exposed rats when compared to VEH controls. (F) In the bursting cells population, the bursting rate of putative pyramidal neurons of adolescent THC-exposed rats was significantly higher than in VEH controls. (G) Representative examples showing bursting activity of putative PFC pyramidal neurons in THC (left) vs. VEH pretreated rats (right). Two-tailed t-tests; **indicated p < 0.01; *indicated p < 0.05. Error bars represent the standard error of the means (SEMs).