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. 2017 Sep 12;7:11420. doi: 10.1038/s41598-017-11645-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Intra-mPFC MUS on adolescent THC-induced sub-cortical hyperdopaminergia. (A) microphotograph of a representative mPFC microsyringe and VTA neuronal recording placements. (B) Increased VTA putative DA neuronal firing frequency in adolescent THC-pretreated rats relative to adolescent VEH-pretreated rats. (C) Before intra-mPFC MUS microinfusion, sub-population of VTA putative DA neurons firing frequency in adolescent THC pretreated rats were significantly increased compared to adolescent VEH pretreated rats. Intra-mPFC MUS reduced firing frequency of VTA putative DA in adolescent THC-pretreated rats relative to adolescent VEH-pretreated rats. (D) Representative rastergram showing the spontaneous activity of 1 putative DA neuron treated with intra-mPFC muscimol in adolescent THC pretreated rat. (E) Increased VTA putative DA neurons bursting levels in adolescent THC vs. VEH pretreated rats. (F) Before intra-mPFC MUS microinfusion, sub-population of VTA putative DA neurons spikes firing in bursts in adolescent THC pretreated rats were significantly increased compared to adolescent VEH pretreated rats. Intra-mPFC MUS reduced spikes firing in bursts of VTA putative DA in adolescent THC-pretreated rats relative to adolescent VEH-pretreated rats. Two-way repeated measures ANOVA or Two-tailed t-tests; **indicated p < 0.01. Error bars represent the standard error of the means (SEMs).