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. 2017 Sep 12;7:11317. doi: 10.1038/s41598-017-10550-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The phenotypes of adult wings. (A) Wild-type adult wing. The area between L2 and L5 veins is measured. The region between L2 and L5 veins of each control wing (A and C) is marked in green and compared in each manipulation (B,D–H) because most of the cell death induced by the suppression of Hh signalling occurs in the presumptive region between the L2 and L5 veins. (B) The hh ^ts adult wing is smaller than the wild-type wing (A). (D) Co-expressing hep-RNAi does not rescue the small size between L2 and L5 compared with the expression of smo-RNAi (C). (E) Co-expressing hid-RNAi increases the indicated area compared with the control wing in C. (F) Co-expressing diap1 increases the indicated area compared with the control wing in C. (G) Co-expressing dronc-RNAi increases the indicated area compared with the control wing in C. (H) Co-expressing drice-RNAi increases the indicated area compared with the control wing in C. (I) The wing area is rescued by co-overexpressing P35. (J and K) Statistics for the green-marked wing regions in each genotype mentioned above. Means ± SEM indicated by ** or *** are significantly different (pairwise comparisons performed using t-tests, p < 0.001 or p < 0.0001). (L) A model of the genetic pathway regulating cell survival by Hh signalling.